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The EXOGEN Device is the only FDA-approved ultrasonic bone growth stimulator device on the market that has demonstrated the ability to accelerate fracture healing in both cortical and cancellous bone.1,2

Interested in learning more about EXOGEN Ultrasound Bone Healing System? Download our patient resource guide.

What is bone stimulation?

Fractured bones go through a natural healing process that includes the growth of both bone mass and density. Through extensive research,1-4 Bioventus has demonstrated that one of the most effective ways to encourage regenerative bone growth is through bone stimulation. The Bioventus Ultrasound Bone Healing System delivers bone stimulation through the use of ultrasonic waves.

How does the EXOGEN Ultrasound Bone Healing System help to stimulate bone growth?

The healing process of a fractured bone includes several stages, beginning with inflammation after the injury and ending with remodeling that produces a strong healed bone. Sometimes this biological process is delayed due to many factors and the bone does not heal properly or completely. EXOGEN's ultrasonic bone growth stimulator device treats the bone at the fracture site by stimulating the growth process and by increasing the production of important growth cells.5-9

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  1. Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF. Acceleration of tibial fracture-healing by non-invasive low-intensity pulsed ultrasound. J Bone Joint Surg Am. 1994;76(1):26-34.
  2. Kristiansen TK, Ryaby JP, McCabe J, Frey JJ, Roe LR. Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. J Bone Joint Surg Am. 1997;79(7):961-973.
  3. Schofer M, Schmelz A, Schultz M. Comparative effectiveness of pulsed ultrasound vs. sham treatment of tibia fracture in patients with delayed and nonunion; a double-blind, multi-center randomized controlled trial. Paper presented at: American Academy of Orthopaedic Surgeons Annual Meeting; March 2010; New Orleans.
  4. Nolte PA, van der Krans A, Patka P, Janssen IM, Ryaby JP, Albers GH. Low-intensity pulsed ultrasound in the treatment of nonunions. J Trauma. 2001;51(4):693-703.
  5. Pounder NM, Harrison AJ. Low intensity pulsed ultrasound for fracture healing: a review of the clinical evidence and the associated biological mechanism of action. Ultrasonics. 2008;48(4):330-338.
  6. Sant’Anna EF, Leven RM, Virdi AS, Sumner DR. Effect of low intensity pulsed ultrasound and BMP-2 on rat bone marrow stromal cell gene expression. J Orthop Res. 2005;23(3):646-652.
  7. Naruse K, Miyauchi A, Itoman M, Mikuni-Takagaki Y. Distinct anabolic response of osteoblast to low-intensity pulsed ultrasound. J Bone Miner Res. 2003;18(2):360-369.
  8. Chen YJ, Wang CJ, Yang KD, et al. Pertussis toxin-sensitive Galphai protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts. FEBS Lett. 2003;554(1-2):154-158.
  9. Wang FS, Kuo YR, Wang CJ, et al. Nitric oxide mediates ultrasound- induced hypoxia-inducible factor-1 alpha activation and vascular endothelial growth factor-A expression in human osteoblasts. Bone. 2004;35:114-123