EXOGEN helps speed up bone healing time.
In studies where the EXOGEN bone stimulator device was used during each stage of the bone healing process, data showed that EXOGEN accelerates indicated* fresh fracture healing by 38%.1,2 And in cases where the bone wasn't healing, when EXOGEN treatment was added, there was a high heal rate of 86% for non-unions.*3
The EXOGEN Bone Healing System is an external, noninvasive orthobiologic that works at the cellular level. It upregulates critical growth factors4-8 that stimulate the bone and speed up the bone healing process.
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EXOGEN Ultrasound Bone Healing System
- Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF. Acceleration of tibial fracture-healing by non-invasive low-intensity pulsed ultrasound. J Bone Joint Surg Am. 1994;76(1):26-34.
- Kristiansen TK, Ryaby JP, McCabe J, Frey JJ, Roe LR. Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. J Bone Joint Surg Am. 1997;79(7):961-973.
- Nolte PA, van der Krans A, Patka P, Janssen IM, Ryaby JP, Albers GH. Low-intensity pulsed ultrasound in the treatment of nonunions. J Trauma. 2001;51(4):693-703.
- Pounder NM, Harrison AJ. Low intensity pulsed ultrasound for fracture healing: a review of the clinical evidence and the associated biological mechanism of action. Ultrasonics. 2008;48(4):330-338.
- Sant’Anna EF, Leven RM, Virdi AS, Sumner DR. Effect of low intensity pulsed ultrasound and BMP-2 on rat bone marrow stromal cell gene expression. J Orthop Res. 2005;23(3):646-652.
- Naruse K, Miyauchi A, Itoman M, Mikuni-Takagaki Y. Distinct anabolic response of osteoblast to low-intensity pulsed ultrasound. J Bone Miner Res. 2003;18(2):360-369.
- Chen YJ, Wang CJ, Yang KD, et al. Pertussis toxin-sensitive Galphai protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts. FEBS Lett. 2003;554(1-2):154-158.
- Wang FS, Kuo YR, Wang CJ, et al. Nitric oxide mediates ultrasound- induced hypoxia-inducible factor-1 alpha activation and vascular endothelial growth factor-A expression in human osteoblasts. Bone. 2004;35:114-123.