The science behind bone stimulation

The EXOGEN Ultrasound Bone Healing System stimulates growth to help accelerate the broken bone healing process from start to finish.3

The broken bone healing process

This graphic can be found in the EXOGEN mechanism of action brochure.


EXOGEN: Evidence-based medicine for healing

Using non-invasive, low-intensity, pulsed ultrasound (LIPUS), EXOGEN has been clinically proven to provide bone stimulation at each stage of fracture healing.3

  • Inflammation: The EXOGEN bone healing system increases division of periosteal cells in culture and upregulates growth factors that trigger blood vessel formation.4
  • Soft callus: EXOGEN bone stimulation enhances the TGFβ-triggered differentiation of chondrocytes in culture and accelerates the formation of extracellular matrix.5
  • Hard callus: EXOGEN upregulates endochondral ossification6,7 and enhances osteoblast differentiation8 and mineralization.4
  • Bone remodeling: Accelerating both the formation and resorption of bone, EXOGEN speeds the remodeling of the mineralized callus.9

Only EXOGEN uses LIPUS technology to stimulate a clear biological response at the cellular level.10,30 As the only bone healing system that works in just 20 minutes a day, EXOGEN is simple for patients to use, which may encourage patient adherence to treatment plans.

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*Summary of Indications for Use: The EXOGEN Ultrasound Bone Healing System is indicated for the non-invasive treatment of established non-unions† excluding skull and vertebra.

In addition, EXOGEN is indicated for accelerating the time to a healed fracture for fresh, closed, posteriorly displaced distal radius fractures and fresh, closed or Grade I open tibial diaphysis fractures in skeletally mature individuals when these fractures are orthopaedically managed by closed reduction and cast immobilization.

There are no known contraindications for the EXOGEN device. Safety and effectiveness has not been established for individuals lacking skeletal maturity; pregnant or nursing women; patients with cardiac pacemakers; on fractures due to bone cancer; or on patients with poor blood circulation or clotting problems. Some patients may be sensitive to the ultrasound gel. Full prescribing information can be found in product labeling, at www.exogen.com or by contacting customer service at 1-800-836-4080.

†A non-union is considered to be established when the fracture site shows no visibly progressive signs of healing.

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Smith & Nephew: EXOGEN(TM) Bone Healing System