Using the EXOGEN Ultrasound Bone Healing System may improve your odds.

Fractures are often frustratingly slow to heal. Between 5-10% fail to heal on their own,9 leaving patients to choose between continual pain and immobility, or surgery and lengthy rehabilitation.1,2

The location, pattern or severity of some fractures can impede bone healing and increase your risk of healing failure. Common health and lifestyle factors such as obesity, diabetes and tobacco use may also interfere with healing.

Is EXOGEN Ultrasound Bone Healing System Right For You?

Your treating doctor has recommended EXOGEN for you because you recently broke a bone or have a nonunion fracture that is showing no signs of healing.

You recently broke a bone and you want it to heal as quickly as possible.

EXOGEN has been clinically proven to accelerate healing in fresh fractures.5,6

Your fracture shows no sign of healing following the break or you have been diagnosed as having a nonunion fracture.

EXOGEN stimulates the bone healing process, getting you back on the path to healing. EXOGEN has been clinically proven to promote healing of nonunion fractures.7

You are a smoker.

EXOGEN assists your body's healing power, reducing the healing delay typically caused by smoking.4

Common Factors That May Impede Your Natural Bone Healing Process:

  • Tobacco use1
  • Common arthritis medications2
  • Obesity10
  • Diabetes2
  • Infections11
  • Diet and nutrition2 

Silence is the Sound of Bone Healing

The EXOGEN Ultrasound Bone Healing System uses, low-intensity ultrasound waves to enhance your body’s natural bone repair processes.

You can’t hear it working, but EXOGEN’s effects on bone healing have been proven in many clinical studies.


The Science of Bone Healing with EXOGEN

The EXOGEN Bone Healing System uses low-intensity pulsed ultrasound (LIPUS) to enhance the body’s natural healing process:

1 Stimulation

EXOGEN sends ultrasound waves through skin and surrounding soft tissue to reach the site of the bone fracture.

2 Activation

The ultrasound waves activate certain cell receptors, setting off a series of reactions, referred to as a cascade.

3 Upregulation

EXOGEN ultrasound increases upregulation of the processes critical to bone repair.

Within minutes of a bone fracture, the body begins a process to repair the damage. Healing a fracture involves several distinct stages. EXOGEN works at the molecular level to aid in every step along the way.

There are four main stages of bone healing, commonly referred to as stages of inflammation, soft callus, hard callus, and bone remodeling. Here are EXOGEN actions that occur during each of these four stages.


EXOGEN’s ultrasound signal increases cell division in cultures of cells that make up the structure that covers most bones (periosteal cells), and upregulates growth factors that trigger the formation of new blood vessels.14,18

Soft Callus

EXOGEN enhances transforming growth factor beta (TGF-ß), which mediates the differentiation and proliferation of chondrocytes that play a major role in forming the fracture callus.19-20

Hard Callus

EXOGEN upregulates endochondral ossification, a process that is essential to the creation of bone tissue.21,22 EXOGEN also enhances the differentiation of bone marrow stem cells into cells that form bone tissue (osteoblasts).17,23 Finally, EXOGEN enhances the incorporation of the minerals calcium and phosphate into these cells, to add structure and strength to newly formed bone tissue.18

Bone Remodeling

EXOGEN accelerates both the normal formation (remodeling) and recycling (resorption) of bone tissue, for a faster formation of the mineralized callus.23 Mineralized callus is the outer layer of bone tissue that normally forms like scar tissue at the ends of a broken bone once it has healed.23

EXOGEN Turns Your Downtime Into Healing Time

A fracture commonly prevents you from continuing to work or live your life as you were able to before the fracture. When you have a busy life, you want to get back on your feet as soon as possible. When the healing takes longer than normal or shows no progression, you want help that will accelerate the healing of your fracture.

With the EXOGEN Ultrasound Bone Healing System, just 20 minutes each day of treatment can enhance your natural bone-healing power for faster healing, and restore healing to a fracture that has failed to heal (called a nonunion).

At Home, At Your Convenience
Proper daily use is essential for EXOGEN to work. We make that easy, too.

The EXOGEN device is small, lightweight and simple to operate, with an internal usage monitor that automatically records the date, time and duration of each treatment so you can track your daily progress.

EXOGEN has been proven to work—but only if you use it each day as prescribed. Find a time that will suit your daily routine to perform the treatment.

Most patients use EXOGEN while reading, watching television or right before going to bed. Over 90% of patients find it convenient and easy to use the device daily as prescribed.24


We're Here For You

LMT Surgical Customer Service is available to answer your questions and help you stay consistent with your EXOGEN treatment schedule.

For LMT Surgical Customer Service, call 1300 880 155 or email [email protected].