{"id":4516,"date":"2021-10-07T08:16:10","date_gmt":"2021-10-07T08:16:10","guid":{"rendered":"https:\/\/exogen.com\/how-it-works\/"},"modified":"2025-09-19T15:56:45","modified_gmt":"2025-09-19T15:56:45","slug":"how-exogen-works","status":"publish","type":"page","link":"https:\/\/www.exogen.com\/cd\/how-exogen-works\/","title":{"rendered":"How EXOGEN Works"},"content":{"rendered":"

[vc_row row_height_percent=”0″ back_image=”5752″ back_repeat=”no-repeat” back_position=”center bottom” overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”799026″ row_height_pixel=”388″ back_size=”cover” el_class=”inner-banner” css=”.vc_custom_1641923154282{margin-top: 88px !important;margin-bottom: 44px !important;}”][vc_column column_width_percent=”100″ position_vertical=”middle” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”325714″][vc_custom_heading text_color=”color-xsdn” heading_semantic=”h1″ text_size=”fontsize-942846″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-667169″ uncode_shortcode_id=”863360″ text_color_type=”uncode-palette”]How EXOGEN<\/span> Works[\/vc_custom_heading][vc_button size=”btn-lg” radius=”btn-circle” hover_fx=”outlined” border_width=”1″ icon_position=”right” uncode_shortcode_id=”132637″ button_color_type=”uncode-solid” icon=”fa fa-arrow-right2″ link=”url:https%3A%2F%2Fwww.exogen.com%2Fcd%2Fhow-to-get-exogen%2F” button_color_solid=”rgba(0,0,0,0.01)” el_id=”button-transparent”]Get EXOGEN Now[\/vc_button][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”207419″ css=”.vc_custom_1633678120354{margin-top: 0px !important;margin-bottom: 0px !important;}”][vc_column column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”791439″][vc_custom_heading text_color=”color-121277″ text_font=”font-559666″ text_size=”fontsize-242148″ text_weight=”400″ text_transform=”uppercase” text_height=”fontheight-133340″ text_space=”fontspace-572008″ uncode_shortcode_id=”173009″ text_color_type=”uncode-palette”]The Science of Bone Healing with EXOGEN[\/vc_custom_heading][vc_custom_heading text_color=”color-nhtu” heading_semantic=”h4″ text_font=”font-126816″ text_size=”h4″ text_weight=”400″ text_height=”fontheight-133340″ uncode_shortcode_id=”112182″ text_color_type=”uncode-palette”]You can\u2019t hear it working, but EXOGEN\u2019s effects on bone healing have been evaluated in multiple clinical studies.*1-3,5,13-31<\/a><\/sup>[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”162087″ css=”.vc_custom_1633601929955{margin-bottom: 30px !important;}”][vc_column width=”1\/1″][vc_row_inner row_inner_height_percent=”0″ back_color=”color-lxmt” overlay_alpha=”50″ gutter_size=”0″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”188481″ row_height_pixel=”247″ back_color_type=”uncode-palette” limit_content=””][vc_column_inner column_width_percent=”100″ gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″ uncode_shortcode_id=”853484″ el_class=”inner-video”][vc_column_text uncode_shortcode_id=”218892″]<\/a>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=”100″ position_vertical=”middle” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″ uncode_shortcode_id=”720947″ css=”.vc_custom_1634210919511{padding-left: 70px !important;}” el_id=”mech_sec”][vc_custom_heading heading_semantic=”h4″ text_font=”font-555555″ text_size=”h4″ text_weight=”400″ uncode_shortcode_id=”375523″ el_class=”video-title”]EXOGEN Mechanism of Action[\/vc_custom_heading][vc_column_text uncode_shortcode_id=”160065″]<\/i>Watch Now<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/2″][vc_row_inner limit_content=””][vc_column_inner column_width_percent=”100″ gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”125162″ el_class=”icon-list-wrap”][vc_custom_heading text_color=”color-nhtu” heading_semantic=”h4″ text_font=”font-559666″ text_size=”h4″ text_weight=”700″ text_height=”fontheight-143712″ uncode_shortcode_id=”618606″ text_color_type=”uncode-palette”]The EXOGEN Bone Healing System uses safe, painless, low-intensity pulsed ultrasound (LIPUS) to amplify natural bone healing three ways:[\/vc_custom_heading][vc_empty_space empty_h=”2″]

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Stimulation32<\/a><\/sup><\/strong>EXOGEN sends ultrasound waves through the skin, creating movement that stimulates your body\u2019s cells.<\/div> <\/div> <\/div> <\/div>
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Activation33<\/a><\/sup><\/strong>EXOGEN ultrasound activates cells in your body.<\/div> <\/div> <\/div> <\/div>
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Upregulation34<\/a><\/sup><\/strong>Upregulation is increased by EXOGEN ultrasound waves that increase factors that help jump start your body to heal your fracture.<\/div> <\/div> <\/div> <\/div> [\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column column_width_percent=”100″ position_vertical=”middle” align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″ uncode_shortcode_id=”105376″][vc_single_image media=”5255″ media_width_percent=”100″ alignment=”center” uncode_shortcode_id=”348867″][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”194492″][vc_column width=”1\/1″][vc_row_inner row_inner_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ border_color=”color-gyho” border_style=”solid” shift_y=”0″ z_index=”0″ uncode_shortcode_id=”404856″ css=”.vc_custom_1635314496576{margin-bottom: 30px !important;border-top-width: 1px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;border-left-width: 0px !important;padding-top: 100px !important;}” border_color_type=”uncode-palette” limit_content=””][vc_column_inner column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”157637″][vc_custom_heading text_color=”color-107303″ heading_semantic=”h3″ text_font=”font-559666″ text_size=”fontsize-950476″ text_weight=”700″ text_height=”fontheight-143712″ uncode_shortcode_id=”459959″ text_color_type=”uncode-palette”]EXOGEN Enhances Bone Healing at Every Stage\u202035<\/a><\/sup>[\/vc_custom_heading][vc_column_text uncode_shortcode_id=”106679″ css=”.vc_custom_1637078347871{margin-top: 15px !important;padding-top: 0px !important;}”]Within minutes of a bone fracture, the body begins a process to repair the damage. Healing a fracture involves several distinct stages. EXOGEN jumpstarts bone healing by stimulating your body\u2019s natural healing process.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ overlay_alpha=”50″ gutter_size=”4″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”172340″ el_class=”bone-enhance” limit_content=””][vc_column_inner column_width_percent=”100″ gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″ uncode_shortcode_id=”163710″]
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1. Inflammation<\/h3><\/div>
When a bone breaks, white blood cells move in to clean up debris created by the break. This creates inflammation, which triggers the growth of new blood cells\u2014the first stage of healing.<\/div> <\/div> <\/div> <\/div>
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3. Hard Callus<\/h3><\/div>
The body gradually replaces the soft callus with a hard callus, connecting the bone fragments more solidly. The stronger callus, which creates a bulge at the site of the fracture, can generally be seen in X-rays just a few weeks after the facture occurs.<\/div> <\/div> <\/div> <\/div> [\/vc_column_inner][vc_column_inner column_width_percent=”100″ gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″ uncode_shortcode_id=”183196″]
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2. Soft Callus<\/h3><\/div>
Blood cells divide and multiply near the break, and new blood vessels develop to fuel the repair process. The body also begins to create fibrous tissue to bridge the break in the bone. This material is called soft callus.<\/div> <\/div> <\/div> <\/div>
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4. Bone Remodeling<\/h3><\/div>
In the final stage of bone fracture healing, the body replaces old bone with new in a process called remodeling. Remodeling makes bones stronger and more compact, and blood circulation in the bone improves.<\/div> <\/div> <\/div> <\/div> [\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”760193″ css=”.vc_custom_1635314552864{border-bottom-width: 0px !important;padding-bottom: 50px !important;}” limit_content=””][vc_column_inner column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”184584″][vc_button button_color=”color-207599″ size=”btn-sm” radius=”btn-circle” hover_fx=”full-colored” border_width=”0″ icon_position=”right” uncode_shortcode_id=”622441″ button_color_type=”uncode-palette” icon=”fa fa-arrow-right2″ link=”url:https%3A%2F%2Fwww.exogen.com%2Fcd%2Fis-exogen-right-for-me%2F”]Learn if EXOGEN is right for you[\/vc_button][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”513352″ css=”.vc_custom_1641804520123{margin-top: 0px !important;}”][vc_column width=”1\/1″][vc_column_text uncode_shortcode_id=”108644″ css=”.vc_custom_1641804508320{margin-top: 0px !important;}”]\u2020In vivo data is not representative of clinical results[\/vc_column_text][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ border_color=”color-gyho” border_style=”solid” shift_y=”0″ z_index=”0″ uncode_shortcode_id=”450817″ css=”.vc_custom_1633678314687{margin-top: 20px !important;margin-bottom: 0px !important;border-top-width: 1px !important;padding-top: 20px !important;}” el_id=”description_text” border_color_type=”uncode-palette”][vc_column width=”1\/1″][vc_column_text uncode_shortcode_id=”141353″]* As of 6\/17\/21, these studies, which reflect the body of evidence of the bone stimulator EXOGEN, include evaluations of applications outside the approved label. Assignment of evidence levels was based on the updated level of evidence rating system in the Oxford Level of Evidence Criteria.
\n\u2020<\/sup>In vivo data is not representative of clinical results[\/vc_column_text][vc_column_text uncode_shortcode_id=”151855″]Summary of Indications for Use<\/strong><\/p>\n

The EXOGEN Ultrasound Bone Healing System is indicated for the non-invasive treatment of established nonunions* excluding skull and vertebra. The EXOGEN device has also been reported as effective as an adjunctive non-invasive treatment of established nonunions in patients:<\/p>\n