{"id":94,"date":"2021-10-07T13:25:46","date_gmt":"2021-10-07T13:25:46","guid":{"rendered":"https:\/\/exogen.com\/?page_id=94"},"modified":"2024-12-19T14:46:05","modified_gmt":"2024-12-19T14:46:05","slug":"the-science-behind-exogen","status":"publish","type":"page","link":"https:\/\/www.exogen.com\/en\/the-science-behind-exogen\/","title":{"rendered":"The Science Behind EXOGEN"},"content":{"rendered":"

[vc_row row_height_percent=”0″ back_color=”color-jevc” back_image=”8978″ back_repeat=”no-repeat” back_position=”center center” overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”805524″ row_height_pixel=”460″ back_size=”cover” el_class=”inner-banner” css=”.vc_custom_1680726059887{margin-top: 88px !important;margin-bottom: 44px !important;}” back_color_type=”uncode-palette”][vc_column column_width_percent=”100″ position_vertical=”middle” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″ uncode_shortcode_id=”652607″][vc_custom_heading text_color=”color-xsdn” heading_semantic=”h1″ text_size=”fontsize-942846″ text_weight=”400″ uncode_shortcode_id=”208518″ text_color_type=”uncode-palette”]The Science Behind EXOGEN<\/span>[\/vc_custom_heading][vc_button size=”btn-lg” radius=”btn-circle” hover_fx=”outlined” border_width=”1″ icon_position=”right” uncode_shortcode_id=”392026″ button_color_type=”uncode-solid” icon=”fa fa-arrow-right2″ link=”url:%2Fcontact-an-exogen-rep%2F” button_color_solid=”rgba(0,0,0,0.01)” el_id=”button-transparent”]Contact an EXOGEN Rep[\/vc_button][\/vc_column][vc_column width=”1\/2″][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”122321″ css=”.vc_custom_1634309459576{margin-top: 40px !important;margin-bottom: 20px !important;}”][vc_column column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/12″ uncode_shortcode_id=”791439″][\/vc_column][vc_column column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ border_color=”color-wvjs” shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”10\/12″ uncode_shortcode_id=”377700″ css=”.vc_custom_1634614556696{border-top-width: 0px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;border-left-width: 0px !important;}” border_color_type=”uncode-palette”][vc_custom_heading text_color=”color-121277″ text_font=”font-559666″ text_size=”fontsize-242148″ text_weight=”700″ text_space=”fontspace-572008″ uncode_shortcode_id=”690869″ text_color_type=”uncode-palette”]The EXOGEN Bone Healing System uses FDA-approved safe, painless, low-intensity ultrasound waves to amplify your patient\u2019s natural bone repair processes.68<\/a><\/sup>[\/vc_custom_heading][\/vc_column][vc_column width=”1\/12″][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”162087″ css=”.vc_custom_1633601929955{margin-bottom: 30px !important;}”][vc_column width=”1\/2″][vc_row_inner row_inner_height_percent=”0″ back_color=”color-763025″ overlay_alpha=”50″ equal_height=”yes” gutter_size=”0″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”114972″ row_height_pixel=”175″ back_color_type=”uncode-palette” el_class=”science-video” limit_content=””][vc_column_inner column_width_percent=”100″ gutter_size=”3″ expand_height=”yes” back_image=”9219″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_visibility=”yes” mobile_width=”0″ width=”5\/12″ uncode_shortcode_id=”508246″ el_class=”video-bg-link”][vc_column_text text_color=”color-107303″ uncode_shortcode_id=”187958″ text_color_type=”uncode-palette” el_class=”text-link”]<\/i> Watch Now<\/a>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=”100″ position_vertical=”middle” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”7\/12″ uncode_shortcode_id=”302825″ css=”.vc_custom_1633614563286{padding-left: 40px !important;}”][vc_custom_heading heading_semantic=”h4″ text_font=”font-555555″ text_size=”h4″ text_weight=”400″ text_height=”fontheight-143712″ uncode_shortcode_id=”203099″ el_class=”video-title”]EXOGEN Mechanism of Action[\/vc_custom_heading][vc_column_text text_color=”color-107303″ uncode_shortcode_id=”129373″ text_color_type=”uncode-palette” el_class=”text-link”]<\/i> Watch Now<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner limit_content=””][vc_column_inner column_width_percent=”100″ gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”125162″ el_class=”icon-list-wrap”][vc_custom_heading text_color=”color-107303″ text_font=”font-559666″ text_size=”fontsize-950476″ text_weight=”700″ text_height=”fontheight-143712″ uncode_shortcode_id=”893861″ text_color_type=”uncode-palette”]Mechanism of Action[\/vc_custom_heading][vc_empty_space empty_h=”2″]

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Stimulation36<\/sup><\/a><\/strong>EXOGEN sends ultrasound waves through skin and surrounding soft tissue to reach the site of the bone fracture.<\/div> <\/div> <\/div> <\/div>
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Activation37<\/sup><\/a><\/strong>The ultrasound waves activate certain cell receptors, setting off a series of reactions, referred to as a cascade.<\/div> <\/div> <\/div> <\/div>
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Upregulation38<\/sup><\/a><\/strong>EXOGEN ultrasound increases upregulation of the processes critical to bone repair.<\/div> <\/div> <\/div> <\/div> [vc_button button_color=”color-207599″ size=”btn-sm” radius=”btn-circle” hover_fx=”full-colored” border_width=”0″ icon_position=”right” uncode_shortcode_id=”554656″ button_color_type=”uncode-palette” icon=”fa fa-arrow-right2″ link=”url:%2Fpatient-case-studies%2F”]Check out Patient Case Studies[\/vc_button][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/2″ uncode_shortcode_id=”102605″][vc_single_image media=”5370″ media_width_percent=”100″ uncode_shortcode_id=”660868″][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ border_color=”color-gyho” border_style=”solid” shift_y=”0″ z_index=”0″ uncode_shortcode_id=”213990″ css=”.vc_custom_1680726247367{border-top-width: 3px !important;padding-top: 100px !important;padding-bottom: 80px !important;}” border_color_type=”uncode-palette”][vc_column column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”102895″][vc_row_inner row_inner_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ uncode_shortcode_id=”694543″ el_id=”Exo_get_wrap” limit_content=””][vc_column_inner column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″ uncode_shortcode_id=”301508″][vc_custom_heading text_color=”color-121277″ heading_semantic=”h3″ text_font=”font-559666″ text_size=”fontsize-242148″ text_weight=”300″ text_space=”fontspace-572008″ uncode_shortcode_id=”148292″ text_color_type=”uncode-palette”]EXOGEN has Multiple Level 1 and 2 Clinical Studies*1-3,5,18-35<\/a><\/sup>[\/vc_custom_heading][vc_empty_space empty_h=”1″][vc_raw_html el_class=”list-step science-step”]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[\/vc_raw_html][vc_empty_space empty_h=”2″][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ border_style=”solid” shift_y=”0″ z_index=”0″ uncode_shortcode_id=”124578″ css=”.vc_custom_1635172221351{border-top-width: 0px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;border-left-width: 0px !important;}” border_color_type=”uncode-solid” border_color_solid=”#979797″ limit_content=””][vc_column_inner column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/12″ uncode_shortcode_id=”109597″][\/vc_column_inner][vc_column_inner column_width_percent=”100″ align_horizontal=”align_center” gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”10\/12″ uncode_shortcode_id=”150387″][vc_column_text border_style=”solid” uncode_shortcode_id=”907529″ css=”.vc_custom_1734619600992{border-top-width: 1px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;border-left-width: 0px !important;padding-top: 30px !important;}” border_color_type=”uncode-solid” el_class=”text-twenty” border_color_solid=”#bfbfbf”]*These studies, which reflect the body of evidence of the bone stimulator EXOGEN, include evaluations of applications outside the approved label. Assignment of evidence levels was based on the updated level of evidence rating system in the Oxford Level of Evidence Criteria. Oxford Centre for Evidence-Based Medicine; www.cebm.ox.ac.uk\/resources\/levels-of-evidence\/ocebm-levels-of-evidence[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/12″][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/1″][vc_column_text text_lead=”small” uncode_shortcode_id=”198455″]*The clinical relevance of in vivo findings is unknown[\/vc_column_text][\/vc_column][\/vc_row][vc_row row_height_percent=”0″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ border_color=”color-gyho” border_style=”solid” shift_y=”0″ z_index=”0″ uncode_shortcode_id=”173764″ css=”.vc_custom_1633889545535{margin-top: 10px !important;margin-bottom: 0px !important;border-top-width: 0px !important;}” el_id=”description_text” border_color_type=”uncode-palette”][vc_column width=”1\/1″][vc_column_text uncode_shortcode_id=”483187″]*The clinical relevance of in vivo findings is unknown<\/p>\n

Summary of Indications for Use<\/strong><\/p>\n

The EXOGEN Ultrasound Bone Healing System is indicated for the non-invasive treatment of established nonunions* excluding skull and vertebra. The EXOGEN device has also been reported as effective as an adjunctive non-invasive treatment of established nonunions in patients:<\/p>\n