ABOUT
EXOGEN
Ultrasound Bone Healing System
MANY FRACTURES ARE SLOW TO HEAL ON THEIR OWN. ONE IN 20 DON’T HEAL AT ALL.4,5
Using the EXOGEN Ultrasound Bone Healing System can improve your odds.
Fractures are often frustratingly slow to heal. Between 5-10% of fractures fail to heal on their own,11 leaving patients to choose between either continual pain and immobility or surgery and lengthy rehabilitation.4,5
The location, pattern or severity of some fractures can impede bone healing and increase your risk of healing failure. Common health and lifestyle factors such as obesity, diabetes and tobacco use may also interfere with healing.
Is EXOGEN Ultrasound Bone Healing System Right For You?
You recently broke a bone and you want it to heal as quickly as possible.
EXOGEN has been clinically proven to accelerate fracture healing of indicated bones* by 38%.1,2
Your fracture shows no sign of healing following the break or you have been diagnosed as having a nonunion fracture.
EXOGEN stimulates the bone healing process, getting you back on the path to healing. EXOGEN has been clinically proven to promote healing for 86% of nonunion fractures.3
You are a smoker.
EXOGEN amplifies your body's healing power, reducing the healing delay typically caused by smoking.7
Silence is the Sound of Bone Healing
The EXOGEN Bone Healing System uses safe, painless, low-intensity ultrasound waves to amplify your body’s natural bone repair processes.
- 38% faster healing of fresh fractures*1-2
- 86% healing of nonunions (fractures not healing on their own)*3
You can’t hear it working, but EXOGEN’s effects on bone healing have been proven in more than double the clinical trials of all other bone healing systems combined.15
The Science of Bone Healing with EXOGEN
The EXOGEN Bone Healing System uses low-intensity pulsed ultrasound (LIPUS) to amplify natural bone healing three ways:
1 Stimulation
EXOGEN sends ultrasound waves through skin and surrounding soft tissue to reach the site of the bone fracture.
2 Activation
The ultrasound waves activate certain cell receptors, setting off a series of reactions, referred to as a cascade.
3 Upregulation
EXOGEN ultrasound increases upregulation of the processes critical to bone repair.
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Preclinical Studies Have Shown That EXOGEN Enhances Bone Healing at Every Stage9
Within minutes of a bone fracture, the body begins a process to repair the damage. Healing a fracture involves several distinct stages. EXOGEN works at the molecular level to aid in every step along the way.
Hard Callus
EXOGEN upregulates endochondral ossification, a process that is essential to the creation of bone tissue.25,26 EXOGEN also enhances the differentiation of bone marrow stem cells into cell that form bone tissue (osteoblasts).21,27 Finally, EXOGEN enhances the incorporation of the minerals calcium and phosphate into these cells, to add structure and strength to newly formed bone tissue.22
Bone Remodeling
EXOGEN accelerates both the normal formation (remodeling) and recycling (resorption) of bone tissue, for a faster formation of the mineralized callus.27 Mineralized callus is the outer layer of bone tissue that normally forms like scar tissue at the ends of a broken bone once it has healed.27
EXOGEN Turns Your Downtime Into Healing Time
A fracture commonly prevents you from continuing to work or live your life as you were able to before the fracture. When you have a busy life, you want to get back on your feet as soon as possible. When the healing takes longer than normal or shows no progression, you want help that will accelerate the healing of your fracture.
With the EXOGEN Ultrasound Bone Healing System, just 20 minutes a day of safe, painless treatment can amplify your natural bone-healing power for faster healing, and restore healing to a fracture that has failed to heal (called a nonunion).
At Home, At Your Convenience
Proper daily use is essential for EXOGEN to work. We make that easy, too.
The EXOGEN device is small, lightweight and simple to operate, with an internal usage monitor that automatically records the date, time and duration of each treatment so you can track your daily progress.
EXOGEN has been proven to work—but only if you use it each day as prescribed. That’s why the EXOGEN CONNECTS smartphone app is highly recommended to ensure your consistent daily use of EXOGEN. Easy-to-follow instructions, how-to-use videos and other free resources also help ensure a hassle-free treatment experience.
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Most patients use EXOGEN while reading, watching television or right before going to bed. Over 90% of patients find it convenient and easy to use the device daily as prescribed.15
We're Here For You
Bioventus Customer Care is available to answer your questions and help you stay consistent with your EXOGEN treatment schedule.
For Bioventus Customer Care, call 1-855-771-0606.).
It’s Time to Heal your Fracture: EXOGEN CONNECTS Keeps You on Track
EXOGEN CONNECTS is our free, smartphone app that automatically sends daily reminders to help you stay on track with your 20-minute a day treatment schedule.
It’s easy to download and activate from your app store, and includes helpful tips and information to promote better healing results.
Let EXOGEN CONNECTS help you stay on the road to faster, better healing.
Download EXOGEN CONNECTS
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If Your Bone Fracture Has Failed to Heal,
Choose EXOGEN With Confidence
The EXOGEN Performance Program is a Bioventus program that refunds patients their out-of-pocket payment for EXOGEN if progression of healing is not shown per criteria below. It is also designed to help reinforce patients’ adherence to the prescribed treatment.
Criteria
All patients who have purchased an EXOGEN designed for the treatment of a fracture, which was prescribed by a qualified physician to treat a stable, non-displaced, established nonunion,* delayed union or acute fracture with a fracture gap less than 10 millimeters (excluding vertebra and skull fractures) are eligible. All patients will automatically be enrolled in the program.
Patients must treat their fracture with EXOGEN per product instructions, for a minimum of 120 days and achieve a minimum adherence of 90%.
Evaluation
To be eligible, your prescribing physician must determine that your bone has not healed, or progressed to a bony union. The prescribing physician must provide two X-rays of your affected bone, one prior to using EXOGEN, and another taken after 120 days or more of EXOGEN treatment that shows a lack of bony union.
The EXOGEN device contains an internal patient usage monitor that records the date, time and duration of each treatment session. This monitor will be used by Bioventus to confirm that at least 90% treatment adherence is met.
Exclusions
- Fracture types:
- Unstable
- Displaced
- Greater than 10-millimeter fracture gap
- Vertebra and skull
- Pathological
- Modified or altered devices
- Patient treated with EXOGEN 4000+ model
- The EXOGEN Performance Program is void if alternative interventions occur during the 120-day treatment period. If alternative intervention is needed, a new 120-day treatment period begins
- EXOGEN must be purchased and received by the patient directly from Bioventus
- The EXOGEN Performance Program applies only to patients for whom the device was prescribed
- Any other costs associated with the purchase – only the patient’s out-of-pocket payment to Bioventus will be refunded
- Valid only in Canada
You may contact Bioventus Customer Care at 1-855-771-0606 for assistance. All claims must be accompanied by the following:
- Prescribing physician’s assessment: completion of the EXOGEN Performance Program evaluation form
- Letter from the patient requesting a refund (including name, address and payment method)
- Prescribed EXOGEN device returned to Bioventus
Claims must be received by Bioventus within one year of first EXOGEN treatment date.
Bioventus reserves the right to amend or cancel the program at any time.