ABOUT
EXOGEN
Ultrasound Bone Healing System
MANY FRACTURES ARE SLOW TO HEAL ON THEIR OWN. ONE IN 20 DON’T HEAL AT ALL.4,5
Fractures are often frustratingly slow to heal. Between 5-10% of fractures fail to heal on their own,15 leaving patients to choose between either continual pain and immobility or surgery and lengthy rehabilitation.4,5
The location, pattern or severity of some fractures can impede bone healing and increase your risk of healing failure. Common health and lifestyle factors such as obesity, diabetes and tobacco use may also interfere with healing.
Is EXOGEN Ultrasound Bone Healing System Right For You?
You recently broke a bone and you want it to heal as quickly as possible.
EXOGEN has been clinically proven to accelerate fracture healing of indicated bones* by 38%.1,2
Your fracture shows no sign of healing following the break or you have been diagnosed as having a nonunion fracture.
EXOGEN stimulates the bone healing process, getting you back on the path to healing. EXOGEN has been clinically proven to promote healing for 86% of nonunion fractures.3
You are a smoker.
EXOGEN amplifies your body's healing power, reducing the healing delay typically caused by smoking.7
Silence is the Sound of Bone Healing
The EXOGEN Bone Healing System uses safe, painless, low-intensity ultrasound waves to amplify your body’s natural bone repair processes.
- 38% faster healing of indicated fresh fractures*1-2
- 86% healing of nonunions (fractures not healing on their own)*3
You can’t hear it working, but EXOGEN’s effects on bone healing have been proven in more than twice the clinical trials of all other bone healing systems combined.18
The Science of Bone Healing with EXOGEN
The EXOGEN Bone Healing System uses low-intensity pulsed ultrasound (LIPUS) to amplify natural bone healing three ways:
1 Stimulation
EXOGEN sends ultrasound waves through skin and surrounding soft tissue to reach the site of the bone fracture.
2 Activation
The ultrasound waves activate certain cell receptors, setting off a series of reactions, referred to as a cascade.
3 Upregulation
EXOGEN ultrasound increases upregulation of the processes critical to bone repair.
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Preclinical Studies Have Shown That EXOGEN Enhances Bone Healing at Every Stage13
Within minutes of a bone fracture, the body begins a process to repair the damage. Healing a fracture involves several distinct stages. EXOGEN works at the molecular level to aid in every step along the way.
Hard Callus
EXOGEN upregulates endochondral ossification, a process that is essential to the creation of bone tissue.28,29 EXOGEN also enhances the differentiation of bone marrow stem cells into cell that form bone tissue (osteoblasts).31,32 Finally, EXOGEN enhances the incorporation of the minerals calcium and phosphate into these cells, to add structure and strength to newly formed bone tissue.25
Bone Remodeling
EXOGEN accelerates both the normal formation (remodeling) and recycling (resorption) of bone tissue, for a faster formation of the mineralized callus.31 Mineralized callus is the outer layer of bone tissue that normally forms like scar tissue at the ends of a broken bone once it has healed.31
EXOGEN Turns Your Downtime Into Healing Time
Everyone needs a little downtime. But a bone fracture may give you a lot more downtime than you want—especially when fractures take far longer to heal than usual, or don’t heal at all.
With the EXOGEN Ultrasound Bone Healing System, just 20 minutes each day of safe, painless treatment can amplify your natural bone-healing power for faster healing, and restore healing to a fracture that has failed to heal (called a nonunion).
At Home, At Your Convenience
Proper daily use is essential for EXOGEN to work. We make that easy, too.
The EXOGEN device is small, lightweight and simple to operate, with an internal usage monitor that automatically records the date, time and duration of each treatment so you can track your daily progress.
EXOGEN has been proven to work—but only if you use it each day as prescribed. That’s why the EXOGEN CONNECTS smartphone app is highly recommended to ensure your consistent daily use of EXOGEN. Easy-to-follow instructions, how-to-use videos and other free resources also help ensure a hassle-free treatment experience.
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Most patients use EXOGEN while reading, watching television or right before going to bed. Over 90% of patients find it convenient and easy to use the device daily as prescribed.18
We're Here For You
Bioventus Customer Service is available to answer your questions and help you stay consistent with your EXOGEN treatment schedule.
For Bioventus Customer Service, call 1-800-836-4080.
It’s Time to Heal your Fracture: EXOGEN CONNECTS Keeps You on Track
EXOGEN CONNECTS is our free, smartphone app that automatically sends daily reminders to help you stay on track with your 20 minutes a day treatment schedule.
It’s easy to download and activate from your app store, and includes helpful tips and information to promote better healing results.
Let EXOGEN CONNECTS help you stay on the road to faster, better healing.
Download EXOGEN CONNECTS
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If Your Bone Fracture Has Failed to Heal,
Choose EXOGEN With Confidence
EXOGEN has been proven effective for healing 86% of nonunion fractures when used as prescribed.3 If your fracture has failed to heal, the EXOGEN Performance Program is our promise to you. Use EXOGEN daily as prescribed for 120 days. If, at the end of that time, your prescribing physician determines there is no radiographic evidence of progression in bone healing, we'll refund your out-of-pocket costs incurred in obtaining the EXOGEN device.
Program Eligibility
The EXOGEN Performance Program is for patients who have been prescribed the device as an indicated treatment for an FDA-approved nonunion fracture and have paid out-of-pocket expenses for the device.
Program eligibility requirements include:
- Diagnosis by a healthcare professional (HCP) of your nonunion fracture, with no visible signs of progressive healing (skull and spine fractures excluded).
- Confirmed use of EXOGEN 20 minutes a day, for a minimum of 120 days, with a 90% minimum adherence to your prescribed course of treatment.
- Out of pocket payment by the patient received in full by Bioventus.
How It Works
BEFORE YOU START TREATMENT: If EXOGEN is prescribed for you, ask the prescribing HCP to provide your Bioventus sales representative with X-rays and a written evaluation of your diagnosed nonunion fracture before beginning EXOGEN treatment, documenting the lack of healing progression to union of your broken bone.
DURING TREATMENT: As you use the EXOGEN device daily, the internal patient usage monitor will automatically record the date, time and duration of each treatment. This makes it easy to ensure you meet the 90% treatment compliance threshold. Compliance is confirmed by examining the returned device after you’ve completed your course of treatment.
AFTER TREATMENT: Once you’ve used EXOGEN for 120 days or more as prescribed, your physician will take new X-rays to evaluate the progress in healing your broken bone. The assessment of your results must be provided by your prescribing HCP, and submitted with a completed EXOGEN Performance Program assessment form.
Claiming Your Refund
If the prescribing HCP has compared the two X-rays and determines that, after using EXOGEN as prescribed, you’ve not had evidence of bone healing, you can claim a refund of the amount you have paid to Bioventus by contacting the Bioventus Customer Service at 1-800-836-4080. Claims are accepted up to one year after you’ve obtained the EXOGEN device.
Remember that all claims must be accompanied by:
- the prescribing HCP’s written assessment
- a return of the prescribed EXOGEN device
Please note that no refund can be given if an examination of the returned EXOGEN device shows that the device has been rendered inoperative or altered in any way.