ABOUT
EXOGEN
Ultrasound Bone Healing System
MANY FRACTURES ARE SLOW TO HEAL ON THEIR OWN. ONE IN 20 DON’T HEAL AT ALL.4,5
Fractures are often frustratingly slow to heal. Between 5-10% of fractures fail to heal on their own,15 leaving patients to choose between either continual pain and immobility or surgery and lengthy rehabilitation.4,5
The location, pattern or severity of some fractures can impede bone healing and increase your risk of healing failure. Common health and lifestyle factors such as obesity, diabetes and tobacco use may also interfere with healing.
Is EXOGEN Ultrasound Bone Healing System Right For You?
You recently broke a bone and you want it to heal as quickly as possible.
EXOGEN has been clinically proven to accelerate fracture healing of indicated bones* by 38%.1,2
Your fracture shows no sign of healing following the break or you have been diagnosed as having a nonunion fracture.
EXOGEN stimulates the bone healing process, getting you back on the path to healing. EXOGEN has been clinically proven to promote healing for 86% of nonunion fractures.3
You are a smoker.
EXOGEN amplifies your body's healing power, reducing the healing delay typically caused by smoking.7
Silence is the Sound of Bone Healing
The EXOGEN Bone Healing System uses safe, painless, low-intensity ultrasound waves to amplify your body’s natural bone repair processes.
- 38% faster healing of indicated fresh fractures*1-2
- 86% healing of nonunions (fractures not healing on their own)*3
You can’t hear it working, but EXOGEN’s effects on bone healing have been proven in more than twice the clinical trials of all other bone healing systems combined.18
The Science of Bone Healing with EXOGEN
The EXOGEN Bone Healing System uses low-intensity pulsed ultrasound (LIPUS) to amplify natural bone healing three ways:
1 Stimulation
EXOGEN sends ultrasound waves through skin and surrounding soft tissue to reach the site of the bone fracture.
2 Activation
The ultrasound waves activate certain cell receptors, setting off a series of reactions, referred to as a cascade.
3 Upregulation
EXOGEN ultrasound increases upregulation of the processes critical to bone repair.
Preclinical Studies Have Shown That EXOGEN Enhances Bone Healing at Every Stage13
Within minutes of a bone fracture, the body begins a process to repair the damage. Healing a fracture involves several distinct stages. EXOGEN works at the molecular level to aid in every step along the way.
Hard Callus
EXOGEN upregulates endochondral ossification, a process that is essential to the creation of bone tissue.28,29 EXOGEN also enhances the differentiation of bone marrow stem cells into cell that form bone tissue (osteoblasts).31,32 Finally, EXOGEN enhances the incorporation of the minerals calcium and phosphate into these cells, to add structure and strength to newly formed bone tissue.25
Bone Remodeling
EXOGEN accelerates both the normal formation (remodeling) and recycling (resorption) of bone tissue, for a faster formation of the mineralized callus.31 Mineralized callus is the outer layer of bone tissue that normally forms like scar tissue at the ends of a broken bone once it has healed.31
EXOGEN Turns Your Downtime Into Healing Time
Everyone needs a little downtime. But a bone fracture may give you a lot more downtime than you want—especially when fractures take far longer to heal than usual, or don’t heal at all.
With the EXOGEN Ultrasound Bone Healing System, just 20 minutes each day of safe, painless treatment can amplify your natural bone-healing power for faster healing, and restore healing to a fracture that has failed to heal (called a nonunion).
At Home, At Your Convenience
Proper daily use is essential for EXOGEN to work. We make that easy, too.
The EXOGEN device is small, lightweight and simple to operate, with an internal usage monitor that automatically records the date, time and duration of each treatment so you can track your daily progress.
EXOGEN has been proven to work—but only if you use it each day as prescribed. That’s why the EXOGEN CONNECTS smartphone app is highly recommended to ensure your consistent daily use of EXOGEN. Easy-to-follow instructions, how-to-use videos and other free resources also help ensure a hassle-free treatment experience.
Most patients use EXOGEN while reading, watching television or right before going to bed. Over 90% of patients find it convenient and easy to use the device daily as prescribed.18
We're Here For You
Bioventus Customer Service is available to answer your questions and help you stay consistent with your EXOGEN treatment schedule.
For Bioventus Customer Service, call 1-800-836-4080.
It’s Time to Heal
EXOGEN Connects App
At your side 24/7, keeping you connected during your healing journey
Your journey to healing will be easier with a reliable guide at your side. That’s where EXOGEN Connects comes in. Features of the free app include:
- a quick-start guide and instructional videos
- the EXOGEN @Home Experience, with useful tools and resources available 24/7
- the ability to sync treatment reminders with your smart device
EXOGEN Connects also features inspirational user testimonials and opportunities to share your own experiences on social media.
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The EXOGEN Rewards Program
Be rewarded for your daily use of EXOGEN
Better compliance with treatment leads to better health outcomes. The EXOGEN Rewards Program encourages you to comply with your doctor’s treatment plan by easing financial concerns about the out-of-pocket cost of EXOGEN. The program will reimburse you up to $500 of your paid out-of-pocket costs if you are 95% compliant with your daily treatment, and if:
- You use EXOGEN daily for a minimum of 120 days (recorded automatically by the device)
or - Should healing occur prior to 120 days, proof of healing is provided
The EXOGEN Rewards Program Evaluation and Exclusions
Evaluation
The EXOGEN device contains an internal usage monitor that records the date, time and duration of each treatment session. This monitor will be used by Bioventus to confirm that you complied with the treatment regimen at least 95% of the time.
Exclusions
- EXOGEN devices that have been modified or altered
- EXOGEN devices that were not sent to the patient directly from Bioventus
- Patients for whom EXOGEN was not prescribed
- Costs other than the patient’s out-of-pocket payment to Bioventus
- EXOGEN treatment outside the United States
- Patients with any federal, state, or other government plans, including, but not limited to, Medicare (including a Medicare Part D or Medicare Advantage plan), Medicaid, TRICARE/CHAMPUS, Veterans Administration or Department of Defense health coverage, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs or pharmaceutical assistance program
To participate in the EXOGEN Rewards Program, contact Customer Service at 1-800-836-4080 for steps on how to return your device for verification.
If you have healed prior to 120 days, please have the physician who prescribed EXOGEN complete this form and return or fax to the contact listed.