Many patients have difficult-to-heal fractures or fractures they want to heal more quickly. EXOGEN offers a non-surgical option that helps to heal nonunion fractures and accelerates indicated acute fractures, so your patients can resume active lifestyles.*1-3

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EXOGEN is a low-intensity pulsed ultrasound (LIPUS) bone stimulator with over 25 years of proven non-invasive bone healing. Prescribed by more than 10,000 physicians annually to help over a million patients worldwide, EXOGEN has an 86% nonunion heal rate and accelerates the healing of indicated acute fractures by 38%.1-4,12

EXOGEN makes treatment compliance tracking convenient for your patients and verifiable for you, with a built-in treatment tracking calendar.

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See the Results in the Data

The EXOGEN Ultrasound Bone Healing System is like no other. It is the only device with 38% accelerated healing of indicated acute fractures.1,2

Outcomes with EXOGEN:

Accelerated healing in cortical and cancellous bone

  • 58 days and 37 days faster, respectively1,2
  • Fracture healing promoted 41% to 51% faster in patients who smoke9

Accelerated healing of indicated fresh tibia fractures in younger and older patients1,48

  • 42 days and 84 days faster, respectively1,48

Discover the noninvasive choice for resolution of nonunions. In clinical studies, low-intensity pulsed ultrasound waves helped heal nonunion fractures.

EXOGEN is effective:

  • In chronic nonunion fractures that failed to heal at least one year prior to treatment – 86% heal rate3
  • In atrophic, hypertrophic, or infected nonunions25,37,49
  • With challenging, established nonunions – 86% heal rate3
  • With high-energy nonunion fractures – 89% heal rate7
  • For use on nonunions with an interfragment gap up to 10 mm and stable osteosynthesis15

Heal rate of common fractures at risk for nonunions

In many cases, EXOGEN may prevent the need for further surgery.

Humerus- 69.1% heal rate50
Clavicle- 83.3% heal rate51
Scaphoid- 90.7% heal rate52
Radius/Ulna- 83.9% heal rate53
Femur- 76.1% heal rate54
Hand/wrist- 88.5% heal rate55
Ankle- 71.0% heal rate56
Tibia/Fibula- 87%57
Metatarsal- 90% heal rate58
Foot- 83.9% heal rate59

Heal rates based on fractures ages between 181-365 days.50-59

Includes metacarpal, carpal and hamate
§Includes talus, calcaneus, tarsal navicular, cuboid and cuneiform

**These studies, which reflect the body of evidence of the bone stimulator EXOGEN, include evaluations of applications outside the approved label. Assignment of evidence levels was based on the updated level of evidence rating system in the Oxford Level of Evidence Criteria.

Summary of Indications for Use
EXOGEN is indicated for the non-invasive treatment of osseous defects (excluding vertebra and skull) that includes the treatment of delayed unions, nonunions,* stress fractures and joint fusion. EXOGEN is also indicated for the acceleration of fresh fracture heal time, repair following osteotomy, repair in bone transport procedures and repair in distraction osteogenesis procedures.

There are no known contraindications for the EXOGEN device. Safety and effectiveness have not been established for individuals lacking skeletal maturity, pregnant or nursing women, patients with cardiac pacemakers, on fractures due to bone cancer, or on patients with poor blood circulation or clotting problems. Some patients may be sensitive to the ultrasound gel.

Full prescribing information can be found in product labeling, at, or by calling Bioventus Customer Service.

*A nonunion is considered to be established when the fracture site shows no visibly progressive signs of healing.